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This might be related to the fact that the owners of the bitches in this study are committed, well-informed breeders and even though they travel or participate in different competitions, they keep their dogs under more controlled conditions than dog owners in general. In this survey, Ronsse and colleagues demonstrate supportive evidence for the influence on antibody titers due to several factors including aging, estrous stage, number of pregnancies, experience with mating, cases of abortion, management and environmental hygiene. This, in conjunction with an immature body-thermoregulation-system, allows for generalized systemic viral replication [ 12 ]. Oronasal transmission is considered to be the main route of infection, but genital and transplacental transmission may also occur [ 81314 ]. Failure to detect CaHV-1 reactivation in the survey could be due to short, self-limiting reactivations that occurred between sampling and examination periods. Fetal mortality rate is higher in pure breed dogs than hybrid dogs. Even though it is known that antibody titers against CaHV-1 considerably decrease quickly after infection, which could explain why none of the dogs tested positive, it has been reported that antibodies in seropositive animals from kennels may be detected for up to 15 months [ 25 ].

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LR was responsible for the serum analysis.

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127|Canine Herpes and Puppy Fatalities|Dr. Jean Dodds|Pure Dog Talk

Zweig MH, Campbell G. Clinical considerations of canine herpesvirus infection. So, it can only be said that CaHV-1 is not circulating within this specific kennel. Survey on viral pathogens in wild red foxes Vulpes vulpes in Germany with emphasis on parvoviruses and analysis of a DNA sequence from a red fox parvovirus. Nevertheless, veterinarians experience an increased demand for vaccination from owners concerned about CHV1 infection and impact of their breeding success. These pups may be infected during passage through their infected dam's birth canal or, more commonly, by contact with oronasal secretions of the dam or other dogs in the kennel or home. Obviously, there is need for follow-up investigations to find etiological causes of these clinical manifestations.

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